MPI-DS Colloquium: The physics and mathematics of wound healing
MPI-DS Colloquium
- Date: May 29, 2024
- Time: 02:15 PM - 03:15 PM (Local Time Germany)
- Speaker: Prof. Dr. Tanniemola B. Liverpool
- University of Bristol
- Location: Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS)
- Room: Prandtl Lecture Hall and Zoom Meeting ID: 959 2774 3389 Passcode: 651129
- Host: MPIDS / LMP
- Contact: golestanian-office@ds.mpg.de
I will discuss some recent work looking quantitatively at the process of wound healing using ideas from thermodynamics and statistical mechanics. Wound healing is a highly conserved process required for survival of an animal after tissue damage. The wound repair process is not only of great interest in its own right but is also a laboratory to study complex tissue dynamics and regeneration.
Many wounds involve damage to an epithelial (barrier) tissue (like skin) that separates different regions of the body of a living organism. I will describe some recent work on studying wound healing in two dimensional epithelial tissues of a fruit fly pupal wing. This epithelium was chosen because it is transparent and accessible to sophisticated imaging techniques. We use live confocal time-lapse microscopy to follow the behav-iour of cells in a tissue before and after wounding.
I will focus on three cell-behaviours that are generally accepted to contribute to wound re-epithelialisation: cell shape deformation, cell division, and cell migration.
I will describe how we are beginning to use a combination of mathematics, physics and biology to disentangle some of the organising principles behind the complex orchestrated dynamics that lead to wound healing.
Many wounds involve damage to an epithelial (barrier) tissue (like skin) that separates different regions of the body of a living organism. I will describe some recent work on studying wound healing in two dimensional epithelial tissues of a fruit fly pupal wing. This epithelium was chosen because it is transparent and accessible to sophisticated imaging techniques. We use live confocal time-lapse microscopy to follow the behav-iour of cells in a tissue before and after wounding.
I will focus on three cell-behaviours that are generally accepted to contribute to wound re-epithelialisation: cell shape deformation, cell division, and cell migration.
I will describe how we are beginning to use a combination of mathematics, physics and biology to disentangle some of the organising principles behind the complex orchestrated dynamics that lead to wound healing.