Analysis of cell-based forces with Traction Force Microscopy
- Datum: 12.02.2018
- Uhrzeit: 14:00 - 15:00
- Vortragende(r): Isabel Rathmann
- Univesität Münster, Institut für Medizinische Physik und Biophysik
- Ort: Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS)
- Raum: 1.51 (Bernsteinzimmer)
- Gastgeber: MPIDS
- Kontakt: david.zwicker@ds.mpg.de
The ability of cells to generate internal forces and to transmit them to the surrounding environment is essential for many biological processes. Traction force microscopy allows for force measurements at the interface of cell and substrate. This method has already contributed in gaining novel insight into the dynamics of cellular mechanisms. Nevertheless, the exact interplay of the cell forces during adhesion and migration processes is largely unknown.
In this project, traction force microscopy was successfully established and applied to four different cell types - observing differences and similarities. The focus lay on analyzing the directionality of the cell-based forces during cell shape changes and cell migration. Here, a number of important findings were made linking the cell's dynamics to the applied forces.
In this project, traction force microscopy was successfully established and applied to four different cell types - observing differences and similarities. The focus lay on analyzing the directionality of the cell-based forces during cell shape changes and cell migration. Here, a number of important findings were made linking the cell's dynamics to the applied forces.