MPI-DS Colloquium: The physics and mathematics of wound healing

MPI-DS Colloquium

  • Datum: 29.05.2024
  • Uhrzeit: 14:15 - 15:15
  • Vortragende(r): Prof. Dr. Tanniemola B. Liverpool
  • University of Bristol
  • Ort: Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS)
  • Raum: Prandtl Lecture Hall and Zoom Meeting ID: 959 2774 3389 Passcode: 651129
  • Gastgeber: MPIDS / LMP
  • Kontakt:
I will discuss some recent work looking quantitatively at the process of wound healing using ideas from thermodynamics and statistical mechanics. Wound healing is a highly conserved process required for survival of an animal after tissue damage. The wound repair process is not only of great interest in its own right but is also a laboratory to study complex tissue dynamics and regeneration.
Many wounds involve damage to an epithelial (barrier) tissue (like skin) that separates different regions of the body of a living organism. I will describe some recent work on studying wound healing in two dimensional epithelial tissues of a fruit fly pupal wing. This epithelium was chosen because it is transparent and accessible to sophisticated imaging techniques. We use live confocal time-lapse microscopy to follow the behav-iour of cells in a tissue before and after wounding.
I will focus on three cell-behaviours that are generally accepted to contribute to wound re-epithelialisation: cell shape deformation, cell division, and cell migration.
I will describe how we are beginning to use a combination of mathematics, physics and biology to disentangle some of the organising principles behind the complex orchestrated dynamics that lead to wound healing.
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