Mechanics and dynamics of biological adhesion

Mechanics and dynamics of cellular contacts

Mechanics and dynamics of adhesion during early development of Dictyostelium discoideum

Cell-substrate adhesion of eukaryotes still remains to be fully understood. As Dictyostelium discoideum  (D.d.) lacks integrins, it is ideally suited to study alternative adhesion properties reflective of eukaryotic evolution with Single Cell Force Spectroscopy (SCFS, Figure 1).

 

Figure 1:
SCFS assay. Side view of cell attached to cantilever. Below: Force-separation curve.