Mechanics and dynamics of biological adhesion

Mechanics and dynamics of cellular contacts

In a further study on cellular contacts and in collaboration with the Luther-group, the goal is to use ECIS setups to obtain quantitative results on the electromechanical coupling and connectivity of primary co-cultures of rat cardiac myocytes and Fibroblasts in vitro. We analyze cardiac contraction dynamics with the ECIS method and combine it with confocal microscopy as shown in Figure 5.

Figure 5:
(Left) Coculture of cardiac myocytes and fibroblasts stained for alpha-actinin (red), vimentin (green), connexin 43 (yellow) and DNA (blue, Dapi). (Right) Contractile dynamics of cocultures with varying fibroblast fractions detected via ECIS impedance spectroscopy for the real part at 4kHz.

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