Mechanics and dynamics of biological adhesion

Mechanics and dynamics of cellular contacts

The arrangement of cells analyzed on bright field images reveals synchronous formation of cell aggregates contributing to impedance oscillations (Figure 3B), while a decrease of circularity <C> occurs out-of phase. Modeling calculations show that cells in united structures generate higher impedance values than the same number of isolated cells [4]. In addition, we analyze starving cells in microfluidic devices in combination with an impedimetric assay (no flow) [5]. The results provide a quantitative understanding of the overall cell morphology, e.g. dynamics of cell-cell and cell-substrate adhesion during early starvation (Figure 4).

 

 

Figure 4:
Above: Origin of impedance oscillations. Below: Scheme of morphological changes occurring in phase.

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