MPIDS Colloquium: Modeling blood flow and mass transfers in cerebral microcirculation
14:15 - 15:15
Prof. Sylvie Lorthois
Institut de Mécanique des Fluides de Toulouse
Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS)
Prandtl Lecture Hall
After underlying the central role of cerebral microcirculation in brain physiology and in several brain pathologies, I will present the architecture of the microvascular cerebral network and show that it is the superposition of two types of structures: a mesh-like capillary structure, homogeneous over a cut-of length corresponding to the characteristic length of capillary vessels (~ 50 μm), and fractal arborescent structures composed of arteries and veins.
Based on these results, I will present some of the approaches we develop for studying blood flow and/or mass transfer at various scales, most of which are based on methodologies developed for the study of multiphase or reactive flows in porous media. Finally, I will present some perspectives re-lated to the role of cerebral microcirculation in neurodegenerative diseases.