MPIDS Colloquium: Cilium checkpoint and human brain organoids
MPIDS Colloquium
- Date: Mar 27, 2019
- Time: 02:15 PM - 03:15 PM (Local Time Germany)
- Speaker: Prof. Jay Gopalakrishnan
- Laboratory for Centrosome and Cytoskeleton Biology, University of Düsseldorf, Germany
- Location: Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS)
- Room: MPIDS Seminar Room 0.77
- Host: MPIDS
- Contact: azam.gholami@ds.mpg.de
Centrosomes and cilia are conserved cellular structures essential for organism development. The primary cilium is a microtubule-based organelle that is dynamically regulated, with assembly occurring during cell cycle exit, and disassembly coinciding with cell cycle re-entry. By studying microcephaly brain organoids, we identified a “cilium checkpoint” that revealed how a timely cilia disassembly is critical to regulate neural stem cell homeostasis during brain development. Intriguingly, the “cilium checkpoint” is inactivated in glioma cancer stem cells. As a result, cancer stem cells undergo uncontrolled self-renewal. Targeting the cilium checkpoint by chemical or genetic manipulation, we could inhibit glioma self-renewal properties and trigger them to differentiate. I shall also highlight how we use brain organoids to model patient-derived glioma cells invasion and new developments in organoids such as generation of brain organoids with functional optic cups.