MPIDS Colloquium: Branching morphogenesis: the many ways to grow a tree
Mar 20, 2019
14:15 - 15:15
Prof. Arndt Siekmann
Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania Philadelphia, USA
Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS)
MPIDS Seminar Room 0.77
The formation of the correct numbers of arteries and veins is crucial for embryonic development and during tissue regeneration in adult organisms. Furthermore, blood vessels need to acquire appropri-ate diameters for the efficient delivery of blood throughout the body. It has become clear that ge-netic signaling pathways in addition to physiological cues, such as hemodynamic forces, orchestrate blood vessel development. Using zebrafish, we identified several genetic pathways that are im-portant for controlling the migratory behaviors and shapes of endothelial cells during these process-es.
• Sugden W.W., Meissner R., Aegerter-Wilmsen T., Tsaryk R., Leonard E.V., Bussmann J., Hamm M.J., Herzog W., Jin Y., Jakobsson L., Denz C., Siekmann A.F. (2017). Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nature cell biology, 19(6):653-65.
• Hasan S.S., Tsaryk R., Lange M., Wisniewski L., Moore J.C., Lawson N.D., Wojciechowska K., Schnittler H., Siekmann A.F. (2017). Endothelial Notch signalling limits angiogenesis via control of artery formation. Na-ture cell biology, 19(8):928-940.
• Xu C., Hasan S.S., Schmidt, I., Rocha, S.F., Pitulescu, M.E., Bussmann, J., Meyen, D., Raz, E., Adams, R.H., Siekmann, A.F. (2014). Arteries are formed by vein-derived endothelial tip cells. Nature communications, 5, 5758.
• Bussmann J., Wolfe S.A., Siekmann A.F. (2011). Arterial-venous network formation during brain vasculari-zation involves hemodynamic regulation of chemokine signaling. Development, 138 (9):1717-1726.