Address

Max Planck Institute for Dynamics and Self-Organization

Dr. Philip Bittihn

Am Faßberg 17

37077 Göttingen

Niedersachsen

Department of Living Matter Physics

How do complex dynamics and patterns in living systems emerge from stochastic molecular interactions in the cell, how are they coordinated at the population/tissue level, and what role do environmental constraints and interactions play in shaping and maintaining them?

Emergent Dynamics in Living Systems

How do complex dynamics and patterns in living systems emerge from stochastic molecular interactions in the cell, how are they coordinated at the population/tissue level, and what role do environmental constraints and interactions play in shaping and maintaining them? [more]

Dr. Philip Bittihn
Dr. Philip Bittihn
Gauss Fellow

Phone: +49 551 5176-157
Fax: +49 551 5176-102
Room: 1.57

I am a physicist who is fascinated by the extraordinary degree of complexity and emergent dynamics in biological systems. These properties pose a major challenge for explaining observed behavior from first principles, requiring innovative methods to decipher the involved mechanisms and to enable control of dynamic behavior. Coming from a nonlinear dynamics background, I started venturing into biology by investigating experimentally and in reaction-diffusion models how pattern formation processes in the cardiac muscle lead to heart rhythm disorders and identified novel strategies to terminate life-threatening cardiac arrhythmias, based on properties of the underlying heterogeneous medium and the characteristic dynamics of topological defects and activation patterns. Subsequently, together with synthetic and systems biologists, I widened my focus to include stochastic evolutionary, gene regulatory and population dynamics. I am particularly interested multicellular systems, where patterns and coordinated population-level behavior emerge from the coupling of individual constituents through physical, chemical end environmental interactions. My research is driven by the vision that an understanding of how biological dynamics emerge can uncover fundamental design principles and at the same time provide the basis for developing methods for biotechnology and medicine that control these dynamics. For current projects, see the group page (on the right).

Self-organized growth patterns.

A colony of genetically modified E. coli inside a quasi-2D microfluidic chamber, undergoing oscillations in growth and gene expression due to coupling of intracellar dynamics and environmental nutrient diffusion [bioRxiv 575068, see pub. list].

Selected publications:

1.
P. Bittihn, A. Didovyk, L. S. Tsimring, J. Hasty
Engineered phenotype patterns in microbial populations
2.
J. Christoph, M. Chebbok, C. Richter, J. Schröder-Schetelig, P. Bittihn, S. Stein, I. Uzelac, F.H. Fenton, G. Hasenfuß, R.F. Gilmour Jr., S. Luther
Electromechanical Vortex Filaments During Cardiac Fibrillation
3.
P. Bittihn, L. S. Tsimring
Gene Conversion Facilitates Adaptive Evolution On Rugged Fitness Landscapes
4.
Y. Li, M. Jin, R. O'Laughlin, P. Bittihn, L. S. Tsimring, L. Pillus, J. Hasty, N. Hao
Multi-generational silencing dynamics control cell aging
5.
S. R. Scott, M. O. Din, P. Bittihn, L. Xiong, L. S. Tsimring, J. Hasty
A stabilized microbial ecosystem of self-limiting bacteria using synthetic quorum-regulated lysis
6.
P. Bittihn, J. Hasty, L. S. Tsimring
Suppression of Beneficial Mutations in Dynamic Microbial Populations
7.
T. K. Shajahan, S. Berg, S. Luther, V. Krinski and P. Bittihn
Scanning and resetting the phase of a pinned spiral wave using periodic far field pulses
8.
P. Bittihn, M. Hörning, S. Luther
Negative curvature boundaries as wave emitting sites for the control of biological excitable media
9.
S. Luther*, F.H. Fenton*, B.G. Kornreich, A. Squires, P. Bittihn, D. Hornung, M. Zabel, J. Flanders, A. Gladuli, L. Campoy, E.M. Cherry, G. Luther, G. Hasenfuss, V.I. Krinsky, A. Pumir, R.F. Gilmour Jr., E. Bodenschatz
Low-energy control of electrical turbulence in the heart
10.
P. Bittihn, A. Squires, G. Luther, E. Bodenschatz, V. Krinsky, U. Parlitz, and S. Luther
Phase-resolved analysis of the susceptibility of pinned spiral waves to far-field pacing in a two-dimensional model of excitable media
11.
P. Bittihn, A. Squires, G. Luther, E. Bodenschatz, V. Krinsky, U. Parlitz, and S. Luther
Far field pacing supersedes anti-tachycardia pacing in a generic model of excitable media
 
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