LMP Seminar: Physics of the mucociliary clearance. Long-range self-organization of ciliary activity and flow patterns in reconstituted bronchial epithelium
14:00 - 15:00
Dr. Annie Viallat
Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix-Marseille Université, France
Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS)
Seminar Room 0.77, Am Faßberg 17, Göttingen
Mucociliary clearance is a biomechanical mechanism of airway protection. It consists of the active transport along the bronchial tree of mucus, a complex viscoelastic fluid propelled by the coordinated beating of billions of active cilia on the epithelial surface of the respiratory tract. This epithelium exhibits a long range orientational order due to the spatiotemporal organization and coordination of ciliary beat directions that emerges during ciliogenesis. By using reconstitued epitheliums, we present how active cilia self-organize and coordinate their beating directions to create deterministic and periodic fluid flow patterns (1) up to the centimeter scale. We show that this organization results from nonlinear collective effects involving the mechanical coupling between cilia and mucus mediated by long-range hydrodynamic interactions, and the active response of ciliary beats.
1. Khelloufi et al. Scientific Reports, 8, 2447 (2018)